Orthopaedic Oncology (Subscribe)

Categories

Bone Metastases (39)
Management of metastatic cancer deposits in bone
MeSH Search Term "Neoplasm Metastasis"[mesh]
ICD-10 Code C79.5 Secondary malignant neoplasm of bone and bone marrow
SNOMED-CT Term Secondary malignant neoplasm of bone (disorder) Concept ID: 94222008
Synonyms - Secondary malignant neoplasm of bone
Metastatic malignant neoplasm to bone
Secondary malignant neoplasm of bone (disorder)
Metastatic tumour of bone
Metastatic tumor of bone
Secondary cancer of bone
Secondary malignant neoplasm of bone and bone marrow
Osseous metastasis
Bony metastasis
Connective and Soft Tissue Neoplasms (534)
Neoplasms developing from some structure of the connective and subcutaneous tissue, bone, cartilage, muscle, connective tissue, peripheral nerve and fat.
MeSH Search Term "Neoplasms, Connective and Soft Tissue"[mesh]
ICD-10 Code C00-D48 Neplasms
SNOMED-CT Term Neoplasm of connective tissues (disorder) Concept ID: 126598008
Lymphoma (25)
A general term for various neoplastic diseases of the lymphoid tissue.
MeSH Search Term "Lymphoma"[mesh]
ICD-10 Code C81-C96 Malignant neoplasms of lymphoid, haematopoietic and related tissue
SNOMED-CT Term Malignant tumor of lymphoid, hemopoietic AND/OR related tissue (disorder) Concept ID: 269475001
Synonyms - Hematologic malignancy
Haematologic malignancy

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2000 Reconstruction of the Pelvis Using a Segmental Autograft of the Ipsilateral Femur

Reconstruction of the Pelvis Using a Segmental Autograft of the Ipsilateral Femur
J. Puget
Tumours of the pelvis are doubly difficult to manage: not only does the growth have to be removed, but means have to be devised to guard against postoperative loss of function if the tumour site has involved the hip joint. If the acetabulum is involved (Enneking Zone II), the tumour often extends either into the iliac wing (Zone I), or into Zone III (the pubic rami and the obturator foramen), which means that any reconstruction will need to involve either Zones I + II, II + III, or, sometimes, I + II + III.

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Adult Cancer Information Summaries PDQ

Physician Data Query (PDQ) Cancer Information summaries
Alphabetical List of PDQ® Adult Cancer Treatment Summaries

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Atlas Solid Tumors

Atlas of Genetics and Cytogenetics in Oncology and Haematology Editor: Jean-Loup Huret, Genetics DIM, University Hospital, F-86021 Poitiers, France

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Benign and Malignant Soft Tissue Tumors eMedicine

Present achievements in the field of soft tissue tumors are the result of advances in molecular biology, oncogenetics, imaging techniques, immunochemistry, diagnosis by fine-needle aspiration, surgical reconstruction, radiation therapy, and tissue banking. Benign soft tissue tumors are fairly common and are treated with surgery alone. Prior to the 1970s, surgery was the primary therapy for malignant soft tissue tumors, and most patients with high-grade tumors had a poor prognosis and a significant mortality rate. Since the mid-1970s, radiation therapy, chemotherapy, and advanced surgical techniques have helped increase long-term survival and decrease the need for ablative surgery. Future advances in molecular oncology may further improve diagnostic, prognostic, and treatment protocols for patients with soft tissue sarcomas.

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Bone Tumour Database

Short clinical synopsis with illustrations of hundreds of bone tumor cases

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Cemented distal femoral endoprostheses for musculoskeletal tumor CORR Open Access

Questions/purposes We asked whether newer, modular distal femoral components had improved survivorship compared with older, custom-casted designs.
Conclusions Cemented modular rotating-hinge distal femoral endoprostheses demonstrated improved survivorship compared with custom-casted implants during this three-decade experience. Patients with low-grade disease and long-term survivors of high-grade localized disease should expect at least one or more revision procedures in their lifetime.
Cemented distal femoral endoprostheses for musculoskeletal tumor: improved survival of modular versus custom implants. Schwartz AJ, Kabo JM, Eilber FC, Eilber FR, Eckardt JJ. Clin Orthop Relat Res. 2010 Aug;468(8):2198-210 (full text)

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Cemented Endoprosthetic Reconstruction of the Proximal Tibia - How Long Do They Last

Questions/purposes - (1) How long do proximal tibial endoprostheses last? (2) What is the typical long-term functional result after proximal tibial replacement? And (3) what are the short- and long-term complications associated with endoprosthetic reconstruction of the proximal tibia, particularly with respect to the soft tissue reconstruction?
Conclusions - Cemented endoprosthetic reconstruction of the proximal tibia provides a reliable method of reconstruction following tumor resection.
Cemented Endoprosthetic Reconstruction of the Proximal Tibia: How Long Do They Last? Adam J. Schwartz, J. Michael Kabo, Fritz C. Eilber, Frederick R. Eilber and Jeffrey J. Eckardt

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Clinical Trials

Database of clinical trials maintained by US National Institute of Health

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Enhanced apoptosis of soft tissue sarcoma cells with chemotherapy: A potential new approach using TRAIL

J Orthop Surg (Hong Kong). 2001 Dec;9(2):19-22 Clayer M, Bouralexis S, Evdokiou A, Hay S, Atkins GJ, Findlay DM. The Queen Elizabeth Hospital, Adelaide, Australia.
Soft tissue sarcomas are less responsive to conventional chemotherapy when compared to bone sarcomas. We investigated the possibility of enhancing the efficacy of chemotherapy by utilising the recently identified cytokine, tumour necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) in combination with standard chemotherapeutic agents. Fresh human soft tissue sarcomas (rhabdomyosarcoma, fibrosarcoma, malignant fibrous histiocytoma) were obtained at biopsy and dispersed tumour cells were incubated in cell culture with standard cytotoxic agents, either as single agents or in combination with TRAIL. The chemotherapeutic agents were, at best, moderately effective, in terms of induction of cellular apoptosis, although the fibrosarcoma was completely unresponsive to all single agents. TRAIL alone had no effect on any sarcoma cell culture. In contrast, the addition of TRAIL and drug together produced a significant increase in sarcoma cell apoptosis, with TRAIL and doxorubicin the most effective combination.

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Highlights of the ISOLS-MSTS 2009 Meeting

Highlights of the ISOLS/MSTS 2009 Meeting: Editorial Comment John H. Healey, Mary I. O’Connor and Mark C. Gebhardt CORR volume 468, Issue 11 full text
Despite much progress in the last three decades, our patients with musculoskeletal neoplasms deserve better outcomes and quality of life from limb salvage procedures than we currently provide. To accomplish this, we in the profession must direct our attention to more research, more education, and more innovation to minimize disease and preserve patient function. While there are many obstacles to understanding and treating musculoskeletal neoplastic disease, the international community has shown its ability to leverage intellectual and societal resources to make progress. An outstanding example of this was the first combined meeting of the International Society of Limb Salvage (ISOLS) and the Musculoskeletal Tumor Society (MSTS) held in Boston in September 2009. Such collaborative efforts allow orthopaedic surgeons and scientific investigators to document the progress in orthopaedic oncology, highlight the remaining problems with limb salvage, and fertilize clinical and basic research efforts worldwide.

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How Long Do Endoprosthetic Reconstructions for Proximal Femoral Tumors Last

Questions/purposes (1) What is the long-term survival of cemented bipolar proximal femoral replacements? (2) How does prosthesis survival compare to patient survival among patients with Stage I, II, and III disease? (3) Do modular implants outperform custom-built prostheses? (4) Do some proximal femoral replacements require conversion to THA?
Conclusions Cemented bipolar proximal femoral replacements after tumor resection proved a durable reconstruction technique. The implants outlived patients with metastatic disease and high-grade localized disease while patients with low-grade disease outlived their implants. The survival of modular prostheses was comparable to that of older, one-piece custom designs.
How Long Do Endoprosthetic Reconstructions for Proximal Femoral Tumors Last? Nicholas M. Bernthal, Adam J. Schwartz, Daniel A. Oakes, J. Michael Kabo and Jeffrey J. Eckardt CORR Volume 468, Issue 11 full text

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Limb Salvage

Definition Limb salvage surgery is a type of surgery primarily performed to remove bone and soft-tissue cancers occurring in limbs in order to avoid amputation. Encyclopedia of Surgery: A Guide for Patients and Caregivers

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Little advantage to limb-sparing surgery compared to amputation in cancer patients

Limb-sparing surgery, which has been taking the place of amputation for bone and soft tissue sarcomas of the lower limb in recent years, may not provide much or even any additional benefit to patients according to a new review. The analysis, published in the September 15, 2009 issue of Cancer, a peer-reviewed journal of the American Cancer Society, indicates that patients and physicians should rethink the pros and cons of limb-sparing surgery and amputation.
Patients with tumors of the bone or soft tissue in their arms and legs require surgery to remove their cancer. To compare the costs and benefits of amputation compared with limb-sparing surgery in these patients, Canadian researchers Ronald Barr, M.D., M.B., Ch.B., of McMaster University and Jay Wunder, M.D., M.Sc., of the Mount Sinai Hospital and the University of Toronto reviewed all published papers on limb-sparing surgery that also measured patients' functional health and quality of life.
The review found that while limb-sparing surgery is generally as effective as amputation in ridding the patient of cancer, it tends to be associated with more early and late complications.

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Malignant Hand Tumors eMedicine

Although tumors of the hand are rather common, most are benign and only 1-2% are malignant. When evaluating a hand lesion, be judicious and maintain a high index of suspicion for malignancy. Malignant hand tumors are complex and challenging entities for the hand surgeon.
Beckert & Concannon

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Metastatic Carcinoma in Skeletal Muscle Radiology for the Surgeon: Musculoskeletal case 44

MRI features of metastases. Full Text
Alhathlol & Munk Can J Surg, Vol. 52, No. 3, June 2009 246

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