Systemic Disorders (Subscribe)


Drug Reaction (5)
Drugs and medications used for orthopedic conditions and causing musculoskeletal problems
MeSH Search Term "Drug Therapy"[mesh] or "Drug Therapy/adverse effects"[mesh]
ICD-10 Code Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
SNOMED-CT Term Adverse reaction to drug (disorder) Concept ID: 62014003
Synonyms - Drug reaction
Adverse drug effect
Adverse drug reaction
Adverse reaction to drug
ADR - Adverse drug reaction
Haemophilia (9)
Internet resources describing Orthopaedic complications of hemophilia. The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage. Orthopaedic complications include acute hemarthrosis, bleeds into muscle and chronic hemophiliac arthropathy
MeSH Search Term "Hemophilia A"[mesh]
ICD-10 Code D66 Hereditary factor VIII deficiency
See also M36.2 Haemophilic arthropathy
SNOMED-CT Term Hemophilia (disorder) Concept ID: 90935002
Synonyms - Haemophilia
See also 80813006 Hemophilic arthropathy (disorder)
Sarcoid (6)
Internet resources relating to orthopaedic manifestations of sarcoidosis
MeSH Search Term "Sarcoidosis"[mesh]
ICD-10 Code D86 Sarcoidosis
SNOMED-CT Term Sarcoidosis (disorder) Concept ID: 31541009
Synonyms - Boeck's sarcoid
Besnier-Boeck-Schaumann syndrome
Miliary lupoid of Boeck
Lupus pernio of Besnier
Benign lymphogranulomatosis of Schaumann
Darier-Roussy sarcoid
Boeck's sarcoidosis
Sickle Cell Anemia (33)
Musculoskeletal aspect of Sickle Cell Disease, including osteomyelitis, septic arthritis, acute bone infraction and avascular necrosis. A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs.
MeSH Search Term "Anemia, Sickle Cell"[mesh]
ICD-10 Code D57 Sickle-cell disorders
SNOMED-CT Term Sickling disorder due to hemoglobin S (disorder) Concept ID: 417357006
Synonyms - Sickling disorder due to haemoglobin S
Sickle cell disease
Sickle cell syndrome


2011 Distinguishing fibromyalgia from rheumatoid arthritis and systemic lupus in clinical questionnaires

Conclusions A combination of 2 questions ("tenderness to touch" and "difficulty sitting for 45 minutes") plus pain in the lower back, neck, hands and arms, may be useful in the construction of clinical questionnaires aimed at patients with musculoskeletal pain. This combination provided a correct diagnosis in 97% of subjects, with only 7 of 253 subjects misclassified.
Distinguishing fibromyalgia from rheumatoid arthritis and systemic lupus in clinical questionnaires: an analysis of the revised fibromyalgia impact questionnaire (FIQR) and its variant the symptom impact questionnaire (SIQR) along with pain locations Ronald Friend and Robert M Bennett Arthritis Research & Therapy 2011, 13:R58

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Congenital and Metabolic Diseases

There is no single unifying trait for these disorders. Some have their genetic defect well characterized. Others are still waiting for the discovery of the gene or genes which are damaged. The diagnosis requires careful clinical laboratory evaluation and may require testing for enzymes that are only available in research laboratories. Biopsy diagnosis may play an important role, not only in establishing the diagnosis, but providing fresh tissue for molecular and enzyme studies. Acrodermatitis Enteropathica Alagille Syndrome Alkaptonuria (Ochronosis) Alpha-1-Antitrypsin Deficiency Alport Syndrome Amyloid Bannayan-Zonana Syndrome Canavan Disease Common Variable Immunodeficiency Cowden Syndrome Cystic Fibrosis Diabetes Insipidus Down Syndrome (Trisomy 21) Ectodermal Dysplasia Ehlers-Danlos Disease Fabry Disease Fucosidosis Galactosemia Gaucher Disease Glucagonoma Gout Juvenile Hyaline Fibromatosis (Murray-Puretic Syndrome) Mucopolysaccharidoses Necrolytic Migratory Erythema Neurofibromatosis Ochronosis (Alkaptonuria) Osteogenesis Imperfecta Porphyria Proteus Syndrome Pseudogout Pseudoporphyria Refsum's Disease Restrictive Dermopathy Retinitis Pigmentosa Rubinstein-Taybi Syndrome Scurvy (Vitamin C Deficiency) Shwachman-Diamond Syndrome Syndrome of Inappropriate Anti-Diuretic Hormone (SIADH) Tuberous Sclerosis von Hippel-Lindau Disease Williams Syndrome

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